Compound Intelligence

Environmental contaminants such as per- and polyfluoroalkyl substances (PFAS) and toxic metals have been implicated in biological aging, yet their combined effects remain poorly understood. This study evaluated the associations of PFAS, lead, and cad...

Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals notable for their high persistence and extensive applications. With the advancement of detection technologies in recent years, PFAS have been frequently identified in envir...

A substantial body of evidence exists demonstrating that exposure to per- and polyfluoroalkyl substances (PFASs) poses a risk to human health. Data from epidemiological studies of those exposed occupationally or environmentally demonstrate adverse he...

Over the past decade, exposome science has evolved from a conceptual framework into a practical discovery engine for environmental health. By combining high-resolution mass spectrometry, non-targeted analysis, multi-omics integration, wearable sensor...

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants implicated in oxidative stress-related health outcomes. However, most epidemiological studies rely on single baseline measurements, limiting insight into how longitu...

Exposure to certain per- and polyfluoroalkyl substances (PFAS) is associated with adverse pregnancy outcomes in mice and humans. These adverse outcomes are suspected to be due to exposure-related toxic effects on the placenta. This study was designed...

Per- and polyfluoroalkyl substances (PFAS) are a class of toxic chemicals that are ubiquitous in the environment and have contaminated water sources globally. As regulations limiting PFAS concentrations in drinking water are being established by regu...

Per- and Polyfluoroalkyl substances (PFAS) are widespread environmental contaminants linked to various adverse health conditions, including immune dysregulation and inflammation, though cellular mechanisms remain poorly understood. In this study, we ...

GenX, the trade name of hexafluoropropylene oxide dimer acid (HFPO-DA) and its ammonium salt, is a short-chain PFAS that has emerged as a substitute for the legacy PFAS perfluorooctanoic acid (PFOA). However, GenX has turned out to be more toxic than...

Dietary intake can be an important exposure route to per- and polyfluoroalkyl substances (PFASs). Little is known about the bioaccumulation of emerging per- and polyfluoroalkyl ether acids (PFEAs) in garden produce from PFAS-impacted communities and ...

The 18th International Congress on Combustion Byproducts and Human Health Effects (PIC2024) was held in Durham, North Carolina on May 20th-22nd, 2024. The overall goal of this conference, typically organized biannually, is to bring together scholars ...

Congenital heart defects (CHDs) are the most prevalent birth defects, contributing significantly to infant morbidity and mortality. While genetic factors account for a subset of CHDs, environmental exposures during critical periods of cardiac develop...

Human studies involving exposure to trifluoroacetic acid (TFA) and the associated clinical outcomes are typically not considered in standard chemical toxicity assessments. This review aimed to identify and synthesize all available human data on TFA e...

This study tested the impact of a breast cancer screening decision aid (DA) that was adapted to include environmental risk information.

Per- and polyfluoroalkyl substances (PFAS) are recognized as ubiquitous "forever chemicals" with endocrine-disrupting properties. Prenatal exposure to PFAS has been implicated in the disruption of glucose homeostasis, potentially contributing to the ...

Obesity prevalence has more than doubled globally over the last 30 years. Exposure to certain chemicals, obesogens, may promote obesity by disrupting lipid metabolism and adipogenesis. There is an urgent need to better identify obesogens using robust...

Endocrine-disrupting chemicals (EDCs) are a diverse group of environmental pollutants capable of interfering with hormonal and immune system regulation. In recent years, increasing concern has been raised about the effects of chemicals, including bis...

Fetal growth is a critical health outcome influenced by prenatal exposure to environmental chemicals, particularly endocrine-disrupting chemicals (EDCs). Studies have shown that pregnant women are simultaneously exposed to multiple chemicals, illustr...

Per- and polyfluoroalkyl substances (PFAS) are extensively utilized in industrial and consumer applications, such as firefighting foams, textiles, electronics, industrial coatings, food packaging, and household consumer products, due to their excelle...